Bayesian localization microscopy reveals nanoscale podosome dynamics.
Nat Methods. 2012 Feb; 9(2):195-200
Stephen Lockett
09 Mar 2012
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New Finding, Technical Advance
A remarkable improvement in super-resolution optical microscopy is reported that enables the use of commonly used fluorescence labels and achieves a temporal resolution of 4 seconds.
By taking advantage of the natural blinking and photobleaching of fluorescent proteins and dyes, a Bayesian technique utilizing factorial hidden Markov...
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