Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction.
Nat Chem. 2012; Feb 5:Advance Online Publication
Ben Davis1 and Gonçalo Bernardes2
17 Feb 2012
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Technical Advance
Selective reactions that allow precise chemical labeling of proteins and real-time visualization of processes in cells and animals are important tools in chemical biology. However, there still exists a need for reactions with improved kinetics and specificities. In this context, the reactions of tetrazines and strained alkenes are...
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