Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner.
PLoS ONE. 2012; 7(1):e29653
Duarte CW, Willey CD, Zhi D, Cui X, ..., McCubrey RO, Khodarev NN, Weichselbaum RR, Gillespie GY. Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, Mehta T, McCubrey RO, Khodarev NN, Weichselbaum RR, Gillespie GY. PLoS ONE. 2012; 7(1):e29653
The antiproliferative effects of interferon (IFN) and its downstream effectors have been well established for many years. Multilevel defects in IFN pathways are commonly found in malignancies, and application of exogenous IFN or IFN inducers has been shown to possess therapeutic potential in numerous preclinical and clinical studies....
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