Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing.
Nucleic Acids Res. 2012 Feb; 40(3):1240-50
Rudy Juliano
15 Feb 2012
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New Finding
This report describes the novel finding that siRNAs (small interfering RNAs) can regulate RNA splicing within the nucleus via an Ago2-mediated mechanism. Interestingly, siRNAs targeting splice sites did not degrade pre-mRNA. Additionally, miRNA (microRNA)-like duplexes containing mismatches also displayed the ability to alter splicing.
This...
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