Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.
Sci Signal. 2011 Sep 20; 4(191):ra61
Ramel D, Lagarrigue F, Pons V, Mounier J, ..., Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B. Ramel D, Lagarrigue F, Pons V, Mounier J, Dupuis-Coronas S, Chicanne G, Sansonetti PJ, Gaits-Iacovoni F, Tronchère H, Payrastre B. Sci Signal. 2011 Sep 20; 4(191):ra61
This work provides both a novel mechanistic insight into the subversion of mammalian signalling mechanisms by pathogenic bacteria and also provides a potential function for the poorly understood phosphoinositide lipid PtdIns5P (phosphatidylinositol 5-phosphate) in the regulation of growth factor receptor trafficking.
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