Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.
J Clin Invest. 2012 Mar 1; 122(3):1022-36
Bordicchia M, Liu D, Amri EZ, Ailhaud G, ..., Zhang C, Takahashi N, Sarzani R, Collins S. Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, Zhang C, Takahashi N, Sarzani R, Collins S. J Clin Invest. 2012 Mar 1; 122(3):1022-36
The authors describe that hormones produced by the heart, known as cardiac natriuretic peptides (NPs), constitute a novel (and highly promising!) pathway to increase energy dissipation in brown adipose tissue (BAT).
BAT has received major attention over the last decade as a renewed target for anti-obesity therapies. Mammalian brown...
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