RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.
Sci Signal. 2009; 2(99):ra79
Francisco Sanchez-Madrid1 and Juan Manuel Serrador2
08 Jan 2010
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Interesting Hypothesis, New Finding
In this study, the authors show for the first time that, in response to T cell receptor (TCR) engagement, the Rap1-guanosine triphosphate (GTP)-interacting adaptor molecule (RIAM) favours inositol trisphosphate (IP3) synthesis, Ca2+ fluxes, and Ras-ERK activation by translocation of activated/phosphorylated phospholipase C-gammagamma)...
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