Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size.
Sci Signal. 2011; 4(196):ra70
Xin M, Kim Y, Sutherland LB, Qi X, ..., Schwartz RJ, Richardson JA, Bassel-Duby R, Olson EN. Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, Richardson JA, Bassel-Duby R, Olson EN. Sci Signal. 2011; 4(196):ra70
Yap is a transcription factor that is phosphorylated and inhibited by the Hippo pathway through cytoplasmic sequestration and degradation. In this elegant work and by using mouse genetics and biochemical assays, the authors demonstrate that Yap is necessary and sufficient for the growth of cardiomyocytes.
They show that Yap is...
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