Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size.
Sci Signal. 2011; 4(196):ra70
Guillermo Oliver and Sathish Srinivasan
07 Feb 2012
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New Finding
Yap is a transcription factor that is phosphorylated and inhibited by the Hippo pathway through cytoplasmic sequestration and degradation. In this elegant work and by using mouse genetics and biochemical assays, the authors demonstrate that Yap is necessary and sufficient for the growth of cardiomyocytes.
They show that Yap is...
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