Heterozygote advantage as a natural consequence of adaptation in diploids.
Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20666-71
Sellis D, Callahan BJ, Petrov DA, Messer PW. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20666-71
This intriguing theoretical study revives the possible importance of heterozygote advantage for evolutionary dynamics. Once thought to be hugely important for maintaining genetic variation, heterozygote advantage, where the heterozygous genotype has highest fitness, has generally been considered over the last several decades as...
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