Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization.
Sci Signal. 2012; 5(207):ra6
Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X. Sci Signal. 2012; 5(207):ra6
This elegant study provides important clues regarding how the plexin/semaphorin system regulates intracellular signaling pathways thereby controlling axon guidance, immune responses, angiogenesis, and multiple cellular processes involving cell migration.
Whereas prior studies have suggested that the intracellular domain of plexins...
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