Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU.
Mol Microbiol. 2011 Dec; 82(6):1454-67
Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW. Mol Microbiol. 2011 Dec; 82(6):1454-67
This beautifully conducted study not only provides an explanation for the previously controversial observation that yeast SOD1 (superoxide dismutase 1) activates the type III secretion effector, ExoU, of Pseudomonas, it also demonstrates a novel way in which a pathogen uses the eukaryotic ubiquitin system for its own purposes.
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