A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos.
Development. 2012 Jan; 139(2):437-42
Morckel AR, Lusic H, Farzana L, Yoder JA, Deiters A, Nascone-Yoder NM. Development. 2012 Jan; 139(2):437-42
This paper reports on a powerful new tool for the precise manipulation of Rho kinase activity. The approach is simple and could be very widely useful for studies of cell and tissue morphogenesis.
The paper reports on a chemical modification of the Rho kinase inhibitor 'Rockout' that renders this molecule photo-sensitive. With this...
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