Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization.
Sci Signal. 2011; 4(203):ra87
Ueno T, Falkenburger BH, Pohlmeyer C, Inoue T. Sci Signal. 2011; 4(203):ra87
Ueno et al. used two rapamycin-induced dimerization techniques to rapidly alter the PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) membrane concentration and observed distinct cell actin phenotypes depending on the way the manipulation worked.
PI(4,5)P2 has been suggested to trigger multiple cellular events including endocyt phagocytosis...
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