The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.
Nucleic Acids Res. 2011 Nov; 39(21):9390-404
Jean-Louis Mergny
15 Dec 2011
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New Finding
In this study, S. Lattmann et al. employed RNA immunoprecipitation coupled to microarray analysis (RIP-chip) analysis to identify the RNAs associated with the RHAU helicase in vivo. Of approximately 10,000 genes expressed in HeLa cells, 1.2% were significantly enriched in the immunoprecipitated fraction. A majority of these RNAs were...
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