Itk controls the spatiotemporal organization of T cell activation.
Sci Signal. 2011 Oct 4; 4(193):ra66
David Fruman
24 Nov 2011
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New Finding, Technical Advance
This paper identifies a key role for the tyrosine kinase Itk (interleukin-2-inducible T cell kinase ) in coordinating the proper spatiotemporal signals that drive actin polymerization at the immunological synapse. The authors used advanced fluorescent imaging techniques, multiple bioprobes and system-level analysis to track the...
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