A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.
Cell. 2011 Oct 14; 147(2):358-69
Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I. Cell. 2011 Oct 14; 147(2):358-69
This is one of the first studies to show that long noncoding RNAs (lncRNAs) can function as competitive substrates for micro RNAs (miRNAs). The muscle-specific linc-MD1 noncoding RNA sequesters specific miRNAs by acting as a target decoy. This relieves the repression of protein-coding mRNAs that are targets of the same miRNAs. This...
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