BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.
Science. 2011 Oct 28; 334(6055):525-8
Michael B Yaffe
18 Nov 2011
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Controversial
"One Ring to Rule Them All" - in the case of breast cancer 1 (BRCA1), maybe not. The breast and ovarian tumor suppressor BRCA1 contains a C-terminal pair of BRCT domains that bind to phosphoproteins, and a RING finger domain that, in combination with BARD1, functions as an E3 ubiquitin ligase. The relative importance of these do and...
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