Linking RNA polymerase backtracking to genome instability in E. coli.
Cell. 2011 Aug 19; 146(4):533-43
Dutta D, Shatalin K, Epshtein V, Gottesman ME, Nudler E. Cell. 2011 Aug 19; 146(4):533-43
In this report, Dutta and colleagues provide an explanation for how active translation maintains the integrity of the Escherichia coli genome.
The authors find that clashes between the transcription and replication machinery cause double-strand breaks in E. coli due to RNA polymerase backtracking on the gene. These breaks are prevented...
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