Resolution of praziquantel.
PLoS Negl Trop Dis. 2011 Sep; 5(9):e1260
Woelfle M, Seerden JP, de Gooijer J, Pouwer K, Olliaro P, Todd MH. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1260
The importance of this paper stems not from its chemistry, a straightforward resolution of a molecule into its enantiomers, but rather from the clinical, mechanistic and collaborative implications. Consistent with the latter the work is published in an 'open access' journal. Praziquantel (2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino (2,1-alpha)...
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