APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Nat Cell Biol. 2011 Oct; 13(10):1234-43
René Medema
26 Sep 2011
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New Finding
Over the last decade, we have come to understand how signal amplification allows the spindle assembly checkpoint to stall cells in mitosis in response to as much as a single unattached kinetochore. However, all this has raised a big question, of how can a cell quickly shut down such a self-amplifying system once all kinetochores are...
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