Accessing protein conformational ensembles using room-temperature X-ray crystallography.
Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16247-52
Herschel Wade
29 Oct 2012
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Confirmation, Controversial, Good for Teaching, Technical Advance
This article examines the effects of crystal cooling on the conformational dynamics of proteins. Importantly, a thorough examination of protein structure models derived from room-temperature and cryogenic X-ray data collections show that the freezing probably does not trap equilibrium ensembles populated at room temperature. Ins shrinkage...
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