Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.
Cell. 2011 Sep 2; 146:709-19
Jonathan Millar and Graham Buttrick
28 Sep 2011
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Controversial, New Finding
The Dent lab previously reported that the outer kinetochore protein Dam1 is regulated by methylation in budding yeast. Dam1 methylation by the Set1 methyl transferase was proposed to oppose Ipl1 (Aurora B) kinase activity by preventing phosphorylation of Dam1 by Ipl1 {1}. In this recent study, the Dent lab now shows that, like methylation...
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