[CONFERENCE POSTER]: Mevastatin promotes neuronal survival following amyloid beta-induced neurotoxicity through AMP-activated protein kinase activation.
F1000 Poster Based on: Alzheimer's Association International Conference. 2011:P2-243
W Sue Griffin
15 Sep 2011
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New Finding
Mevastatin protection of human neuronal cells from amyloid beta (Abeta) toxicity depends on mevastatin activation of adenosine monophosphate-activated protein kinase (AMPK). In addition to promotion of cell survival, mevastatin also reduces production of phosphorylated tau, which may decrease the formation of neurofibrillary tangles....
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