The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.
Cell. 2010 Jun 25; 141(7):1208-19
This elegant study by Jin et al. provides compelling evidence that the BBSome complex of Bardet-Biedl syndrome (BBS) proteins forms a coat that is recruited to membranes by the BBS protein and small GTPase Arl6/BBS3.
Using biochemical purification, the authors show that GTP-bound Arl6 binds the BBSome, and specifically BBS1. Both...
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