AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
Sci Signal. 2011 Aug 30; 4(188):ra56
Chan JC, Hannan KM, Riddell K, Ng PY, ..., Johnstone RW, McArthur GA, Hannan RD, Pearson RB. Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB. Sci Signal. 2011 Aug 30; 4(188):ra56
This interesting study provides a new perspective on the role of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway in ribosome biogenesis and translation. Most previous studies have focused on the pathway from PI3K, Akt, TSC1/TSC2, Rheb-GTP to TORC1-mediated p70S6k and 4E-binding protein (BP)1...
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