AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
Sci Signal. 2011 Aug 30; 4(188):ra56
Larry Kane and Jing Cheng
12 Sep 2011
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New Finding, Novel Drug Target
This interesting study provides a new perspective on the role of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway in ribosome biogenesis and translation. Most previous studies have focused on the pathway from PI3K, Akt, TSC1/TSC2, Rheb-GTP to TORC1-mediated p70S6k and 4E-binding protein (BP)1...
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