Evaluation of methadone absorption after topical administration to hospice patients.
J Pain Symptom Manage. 2011 May; 41(5):828-35
Sylvester RK, Schauer C, Thomas J, Steen P, Weisenberger A. J Pain Symptom Manage. 2011 May; 41(5):828-35
Robert Sylvester and colleagues have successfully demonstrated that methadone analgesia is not dependent on systemic absorption.
Several particulars of this study need comment. The age disparity (90 years on average for the topical methadone group and 66 years for the oral methadone group) is a concern. Methadone absorption like...
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