Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction.
J Proteomics. 2011 Oct 19; 74(11):2417-29
Chavez JD, Wu J, Bisson W, Maier CS. J Proteomics. 2011 Oct 19; 74(11):2417-29
While acrolein is attracting growing attention as an environmental pollutant due to its presence in automotive exhausts and formation during the cooking of fatty foodstuffs, this groundbreaking study adds to the flourishing interest in its toxicity by identifying this noxious electrophile as a major mediator of spontaneous protein...
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