Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
Science. 2011 Sep 2; 333(6047):1303-7
Guoping Fan and Kevin Huang
10 Nov 2011
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Confirmation, New Finding
This notable paper parallels the study by Ito and colleagues {1} implicating a novel pathway for DNA demethylation. Using a series of biochemical tests, the authors of this paper identify additional Tet-mediated cytosine modifications that are postulated intermediates for DNA demethylation. In addition, the authors propose a model...
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