Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin.
Sci Signal. 2011 Aug 9; 4:ra51
Rony Seger
23 Aug 2011
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New Finding
The data from this study are important as they show that distinct phosphorylation patterns by different G protein-coupled receptor (GPCR) kinases (GRKs) create a 'barcode' that imparts distinct conformations to the recruited beta-arrestin, thus regulating its functional activities.
Phosphorylation of GPCRs on Ser/Thr residues is...
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