Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin.
Sci Signal. 2011 Aug 9; 4:ra51
Nobles KN, Xiao K, Ahn S, Shukla AK, ..., Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Sci Signal. 2011 Aug 9; 4:ra51
The data from this study are important as they show that distinct phosphorylation patterns by different G protein-coupled receptor (GPCR) kinases (GRKs) create a 'barcode' that imparts distinct conformations to the recruited beta-arrestin, thus regulating its functional activities.
Phosphorylation of GPCRs on Ser/Thr residues is...
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