Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia.
J Cell Biol. 2011 Jul 25; 194(2):187-97
Bowen JR, Hwang D, Bai X, Roy D, Spiliotis ET. J Cell Biol. 2011 Jul 25; 194(2):187-97
The authors have shown that the septin cytoskeleton in epithelial cells provides the 3D framework to guide microtubule growth towards the apical domain during polarization of the cell. Septins appear to promote microtubule growth by suppressing catastrophe. They also orient the growth of microtubules that encounter these filaments....
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