Cleavage of cohesin rings coordinates the separation of centrioles and chromatids.
Nat Cell Biol. 2011 Aug; 13(8):966-72
Silke Hauf
22 Mar 2013
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Confirmation, New Finding
Separase triggers anaphase by proteolytically cleaving the cohesin complex. Cohesin binds to chromosomes and holds sister chromatids together. Cleavage of cohesin splits sister chromatids and allows them to move to opposite poles of the cell {1}. A parallel role of separase in disengagement of centrioles had been proposed some years...
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