Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
J Clin Invest. 2011 Jun 1; 121(6):2242-53
Yan F, Cao H, Cover TL, Washington MK, ..., Chaturvedi R, Peek RM, Wilson KT, Polk DB. Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB. J Clin Invest. 2011 Jun 1; 121(6):2242-53
This is a very interesting paper showing that a protein called p40 secreted by Lactobacillus rhamnosus GG (LGG) prevents cytokine-induced apoptosis of epithelial cells. The authors also identify the mechanism that is mediated by the activation of Akt in response to epidermal growth factor receptor (EGFR) triggering. They also show...
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