Activation of a bacterial virulence protein by the GTPase RhoA.
Sci Signal. 2009; 2(95):ra71
Christen M, Coye LH, Hontz JS, LaRock DL, Pfuetzner RA, Megha, Miller SI. Sci Signal. 2009; 2(95):ra71
The paper reports on a new way in which pathogenic bacteria interfere with the function of Rho GTP-binding proteins.
Pathogenic bacteria use the type III secretion system (TTSS) to inject virulence factors into host cells. Many of these interfere with Rho protein function in a variety of ways. They act as guanine nucleotide exchange...
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