Modulated microRNA expression during adult lifespan in Caenorhabditis elegans.
Aging Cell. 2006 Jun; 5(3):235-46
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This novel genome-wide analysis of time-dependent micro RNA (miRNA) gene expression in Caenorhabditis elegans sets the stage for exciting new biogerontology hypotheses.
miRNAs are small, non-coding RNAs that regulate gene expression in
multicellular organisms by blocking or degrading coding messenger RNAs (mRNAs). Gene silencing by miRNA interference underscores the complex layered nature of the regulatory system of eukaryotes, and has been proven key in virtually all cellular processes. A set of highly conserved miRNAs has been identified in the animal kingdom, and reports of key functions in development and aging have begun to appear in model systems (e.g. insects and nematodes) that could be recapitulated in humans. Here, the authors systematically make a genome-wide examination of miRNA expression levels during the adult life of the nematode model C. elegans in a novel attempt to establish a correlation between miRNA expression and the physiological degeneration due to aging. Remarkably, statistically significant variations in the expression levels of the developmental timing regulators let-7 and lin-4, and muscle-specific mir-1, miRNAs were found. This careful analysis establishes that 34 of the 114 miRNA genes examined (50/114 within a 90% confidence interval) appear to deviate from steady state expression during the lifespan of adult worms, predicts the gene targets of these age-regulated miRNAs and suggests implications for the fundamental mechanisms of aging.
Rossi P: F1000Prime Recommendation of [Ibáñez-Ventoso C et al., Aging Cell 2006, 5(3):235-46]. In F1000Prime, 12 Nov 2009; DOI: 10.3410/f.1168016.630123. F1000Prime.com/1168016#eval630123
F1000Prime Recommendations, Dissents and Comments for [Ibáñez-Ventoso C et al., Aging Cell 2006, 5(3):235-46]. In F1000Prime, 18 Jun 2013; F1000Prime.com/1168016
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MicroRNAs (miRNAs) are small, abundant transcripts that can bind partially homologous target messages to inhibit their translation in animal cells. miRNAs have been shown to affect a broad spectrum of biological activities, including developmental fate determination, cell signaling and oncogenesis. Little is known, however, of miRNA contributions to aging. We examined the expression of 114 identified Caenorhabditis elegans miRNAs during the adult lifespan and find that 34 miRNAs exhibit changes in expression during adulthood (P
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