Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Sci Signal. 2009; 2(90):ra58
Gomez MA, Contreras I, Hallé M, Tremblay ML, McMaster RW, Olivier M. Sci Signal. 2009; 2(90):ra58
This paper provides new insights into the underlying mechanism of Leishmania-mediated activation of protein tyrosine phosphatases (PTPs) that leads to the down-regulation of host macrophage signaling pathways and to the intracellular development of the parasite. The strategy that Leishmania exploits to alter host PTP activity during...
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