MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.
Sci Signal. 2009; 2(92):ra62
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. Sci Signal. 2009; 2(92):ra62
The authors provide convincing data that suggest induction of epithelial-mesenchymal transition (EMT) is controlled by microRNAs in the miR-200 microRNA family, and this family of microRNAs is regulated by both a balance and crosstalk between Akt1 and Akt2 activity, and not one single Akt isoform alone. The data suggest that breast...
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