Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
Sci Signal. 2009; 2(78):ra33
Xie L, Xiao K, Whalen EJ, Forrester MT, ..., Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Sci Signal. 2009; 2(78):ra33
The study identifies the beta2-adrenergic receptor (b2AR) as a physiological substrate of the dioxygenase EGLN3 and the von Hippel-Lindau (pVHL) tumor suppressor protein-E3 ligase complex and thus presents the first case of oxygen-dependent proteosomal degradation beyond the hypoxia-inducible factor (HIF), a master regulator of...
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