Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
Sci Signal. 2009; 2(78):ra33
Taina Pihlajaniemi
11 Sep 2009
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New Finding
The study identifies the beta2-adrenergic receptor (b2AR) as a physiological substrate of the dioxygenase EGLN3 and the von Hippel-Lindau (pVHL) tumor suppressor protein-E3 ligase complex and thus presents the first case of oxygen-dependent proteosomal degradation beyond the hypoxia-inducible factor (HIF), a master regulator of...
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