Dopamine controls persistence of long-term memory storage.
Science. 2009 Aug 21; 325(5943):1017-20
Rossato JI, Bevilaqua LR, Izquierdo I, Medina JH, Cammarota M Science. 2009 Aug 21; 325(5943):1017-20
This is a powerful demonstration of a mechanism for systems consolidation. The authors use a simple but effective behavioral inhibitory avoidance task to dissect the influence of dopamine on hippocampal long-term memory. They show that consolidation is controlled by dopaminergic neurons in the ventral tegmental area (VTA) many hours...
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