Direct activation of protein kinases by unanchored polyubiquitin chains.

Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ. Nature. 2009 Sep 3; 461(7260):114-9

Keith Wilkinson

17 Nov 2011 | New Finding

Polyubiquitin chains are covalently attached to proteins in order to target them to different locations or assemble/disassemble macromolecular complexes in signalling pathways. This study is important because it found that polyubiquitin can signal in the cell as unanchored chains, without being attached to other proteins.

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Direct activation of protein kinases by unanchored polyubiquitin chains.

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