Distinct opioid circuits determine the palatability and the desirability of rewarding events.
Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12512-7
Kent Berridge1 and Kyle Smith2
27 Aug 2009
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Confirmation, New Finding
This study nicely demonstrates that distinct opioid substrates in the brain mediate the palatability of reward versus its cognitive-incentive value (act-outcome value).
Wassum et al. trained rats in a two-stage seeking/taking operant task (pressing a "seeking" lever, followed by a second "taking" lever that becomes available by pressing the first lever)...
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