Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Science. 2009 Jul 31; 325(5940):612-6
Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, ..., Mempel TR, Libby P, Weissleder R, Pittet MJ. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Science. 2009 Jul 31; 325(5940):612-6
This work demonstrates that the spleen serves as a reservoir for large quantities of undifferentiated monocytes. After ischemic myocardial injury, splenic monocytes rapidly increase their motility, exit the spleen and accumulate in injured tissue where they participate in wound healing.
Tissue repair after myocardial infarction involves...
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