Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.
Nat Immunol. 2009 Jul; 10(7):786-93
Phan TG, Green JA, Gray EE, Xu Y, Cyster JG. Nat Immunol. 2009 Jul; 10(7):786-93
The results of this paper clearly show that non-cognate retrieval of immune complexed antigen by follicular B cells from subcapsular sinus (SCS) macrophages represents a mechanism for transfer of such antigen to follicular dendritic cells (FDCs). This transfer of immune complexed antigen by follicular B cells is fundamentally important...
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