Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro.
Hepatology. 2009 Sep; 50(3):920-8
March S, Hui EE, Underhill GH, Khetani S, Bhatia SN. Hepatology. 2009 Sep; 50(3):920-8
This paper demonstrates new methods for identifying and maintaining the differentiated phenotype of sinusoidal endothelial cells (SEC) in culture. It therefore has important implications for research into the function of these cells.
Isolated SEC rapidly dedifferentiate in culture. Additionally, definitive identification of these...
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