Gene expression divergence in yeast is coupled to evolution of DNA-encoded nucleosome organization.
Nat Genet. 2009 Apr; 41(4):438-45
Field Y, Fondufe-Mittendorf Y, Moore IK, Mieczkowski P, ..., Lubling Y, Lieb JD, Widom J, Segal E. Field Y, Fondufe-Mittendorf Y, Moore IK, Mieczkowski P, Kaplan N, Lubling Y, Lieb JD, Widom J, Segal E. Nat Genet. 2009 Apr; 41(4):438-45
These findings suggest that yeast promoter sequences have evolved to bind nucleosomes according to lineage-specific gene expression requirements. As such, it ushers in a new paradigm of evolution acting on DNA sequences that code for chromatin states in cis.
This paper continues an important line of work relating genomic DNA sequence...
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