The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
Sci Signal. 2009; 2(58):ra6
John Ladbury
24 Mar 2009
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New Finding
The phosphorylation of the intracellular region of fibroblast growth factor recepter 1 (FGFR1) occurs in a defined order. Disruption of this process through mutation can have pathological consequences. This work, coupled with an earlier paper by this group {1}, should have a profound effect on the way we consider the multiple phosphorylation...
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