AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
Dev Cell. 2009 Feb; 16(2):256-70
Dasgupta B, Milbrandt J. Dev Cell. 2009 Feb; 16(2):256-70
The authors report a profound brain phenotype in AMP-activated protein kinase (AMPK) beta1 mutant mice. Their animals die by P21, display severe tremors, and have 50% reduction in overall brain size. This paper is interesting because AMPK alpha null mice lines have not shown these features.
In eukaryotes, AMPK occurs as an alphgamma...
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