Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.
Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2635-40
Yu JJ, Robb VA, Morrison TA, Ariazi EA, ..., Hensley H, Jordan VC, Walker CL, Henske EP. Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer LF, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2635-40
Lymphangioleiomyomatosis (LAM), a rare cystic lung disease found primarily in women, results from the proliferation of the "LAM cell", which has mutations in the tuberous sclerosis complex (TSC) genes. It is unclear why LAM is found primarily in women. In this article, Yu et al. demonstrate that pulmonary metastasis and survival of...
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