Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell. 2008 Aug 22; 134(4):668-78
Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, ..., Bosanac I, Hymowitz SG, Kelley RF, Dixit VM. Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM. Cell. 2008 Aug 22; 134(4):668-78
Polyubiquitin chains consist of ubiquitin monomers linked to each other covalently by an isopeptide bond between the C-terminus of one ubiquitin and one of the seven lysines (or the N-terminus) of the next ubiquitin. This study is important because it introduces linkage-specific antibodies and uses them to show that the length and...
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