Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.
Nat Neurosci. 2011 Jul; 14(7):848-56
David Sweatt and Jeremy Day
15 Jun 2011
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Confirmation, New Finding
This article elegantly examines the contribution of RNA polymerase II (Pol II) stalling to stimulus-induced gene expression in neurons, revealing that polymerase stalling is a common mechanism by which immediate early genes (IEGs) are poised for rapid transcription in response to neuronal events.
It is well understood that many forms...
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