Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.
Nat Neurosci. 2011 Jul; 14(7):848-56
Saha RN, Wissink EM, Bailey ER, Zhao M, ..., Daigle KR, Fenn JD, Adelman K, Dudek SM. Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang JY, Daigle KR, Fenn JD, Adelman K, Dudek SM. Nat Neurosci. 2011 Jul; 14(7):848-56
This article elegantly examines the contribution of RNA polymerase II (Pol II) stalling to stimulus-induced gene expression in neurons, revealing that polymerase stalling is a common mechanism by which immediate early genes (IEGs) are poised for rapid transcription in response to neuronal events.
It is well understood that many forms...
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