Module map of stem cell genes guides creation of epithelial cancer stem cells.
Cell Stem Cell. 2008 Apr 10; 2(4):333-44
Paul Liu
03 Jun 2008
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Confirmation, Interesting Hypothesis, New Finding, Novel Drug Target, Technical Advance
This fascinating paper identifies two distinct stem cell transcriptional programs, one is embryonic stem cell (ESC)-like and the other adult stem cell-like, and demonstrates that c-Myc is able to induce ESC-like transcriptional program in differentiated cells, a characteristic of cancer stem cells.
Using a method called "gene module...
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